Testosterone replacement therapy (TRT) has become a widely accepted treatment for men experiencing low testosterone levels. While the benefits of TRT include improved energy, muscle mass, mood, and libido, there are important health considerations that must be addressed when undergoing this therapy. One key factor that medical professionals monitor in men on TRT is prostate-specific antigen (PSA) levels. PSA levels are often used as a biomarker for prostate health, and their relationship with testosterone therapy remains a subject of ongoing research and clinical observation. Understanding how PSA and testosterone interact, the potential risks involved, and how often PSA should be checked while on TRT is crucial for men considering or currently undergoing testosterone therapy.